[beta]-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and use of the same

[beta]-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and use of the same

A compound represented by Formula (I), a pharmaceutically acceptable salt or ester, hydrate, solvate or crystalline form thereof is provided: Formula (I). The compound represented by Formula (I) is a [beta]-amino acid derivative, and in Formula (I): X is a single bond or O; Y is NH or C=O; Z is C=O,...

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Bibliographische Detailangaben
Hauptverfasser: FU, CHIH-WEI, CHEN, YI-HSUN, HUNG, CHIU-LIEN, LIU, CHIH-PENG, TU, CHIA-MU
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A compound represented by Formula (I), a pharmaceutically acceptable salt or ester, hydrate, solvate or crystalline form thereof is provided: Formula (I). The compound represented by Formula (I) is a [beta]-amino acid derivative, and in Formula (I): X is a single bond or O; Y is NH or C=O; Z is C=O, C=S, NH,, or; W is C or N; A is a single bond, O, OH, OCH2, a heterocycle or N3; R1 is H or F; R2 is H, F, OH, CF3, CH2OH, CHO or; R3 is H; n is 0 or 1; and m is 0 or 1.