RNA action inhibitor and use thereof

Provided is a target RNA action inhibitor based on RNA interference and ASO. An RNA interference agent of the present invention is provided with a guide strand and a passenger strand against the target RNA, wherein blunt ends are formed at both ends of double stranded RNA obtained through pairing of...

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Bibliographische Detailangaben
Hauptverfasser:	MARUYAMA, SHOICHI, KOKURYO, TOSHIO, YUGUCHI, MOTOKI, TSUBOI, TOSHIKI, DOKE, TOMOHITO, NAKASHA, AYAKA, ISHIMARU, ISAO, SUGITA, TOMOE, ASANUMA, HIROYUKI, ISHIMOTO, TAKUJI, KOTO, AYAKO, MATSUMOTO, MASANORI, KAMIYA, YUKIKO, NISHI, KEISUKE, ASAI, RYOICHI, MURAYAMA, KEIJI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is a target RNA action inhibitor based on RNA interference and ASO. An RNA interference agent of the present invention is provided with a guide strand and a passenger strand against the target RNA, wherein blunt ends are formed at both ends of double stranded RNA obtained through pairing of the passenger strand and the guide strand, and one or more units selected from the group consisting of units represented by formula (1) and formula (2) are provided to: (a) the 5' end side and the 3' end side of the passenger strand; and (b) the 3' end side of the guide strand. Formula (1) (wherein X represents an oxygen atom or a sulfur atom). Formula (2) (wherein X represents an oxygen atom or a sulfur atom).