Liquid compositions comprising a levodopa amino acid conjugate and uses thereof

Disclosed herein are liquid pharmaceutical formulations comprising levodopa amino acid conjugates that may further comprise a decarboxylase inhibitor, such as carbidopa, an antioxidant, a solvent, or any other pharmaceutically acceptable excipient. Further disclosed are methods of treating generativ...

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Hauptverfasser: MOROKUMA, KENJI, GAZAL, ELANA, SHALTIEL-KARYO, RONIT, BEN-HAMO, SHMUEL, NAKAO, AKIRA, ZAWOZNIK, EDUARDO M, OKUNO, MASATAKA, BRAIMAN-WIKSMAN, LIORA, MAINFELD, ALEX, IIJIMA, DAISUKE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Disclosed herein are liquid pharmaceutical formulations comprising levodopa amino acid conjugates that may further comprise a decarboxylase inhibitor, such as carbidopa, an antioxidant, a solvent, or any other pharmaceutically acceptable excipient. Further disclosed are methods of treating generative conditions and/or conditions characterized by reduced levels of dopamine in the brain, such as Parkinson's disease, comprising administering the disclosed liquid pharmaceutical formulations. Disclosed also are LDAA conjugate compounds.