Enhanced performance of amorphous solid and solubilized formulations for achieving therapeutic plasma concentrations

This invention relates to solid amorphous dispersions comprising Compound (I) having the formula and one or more polymers or to solution formulations comprising Compound (I) and one or more co-solvents and surfactants. The formulations exhibit enhanced stability and bioavailability.

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Bibliographische Detailangaben
Hauptverfasser:	ZIEMBA, THERESA M, PATTASSERI, SHABEERALI, REDDY, JAY POORNA, NARASIMHAMURTHY, ROOPA, PAL, SHARMISTHA, STEFANSKI, KEVIN J, WAKNIS, VRUSHALI M, SRIDHAR, SRIKANTH KORAVADY, PANDURANGA, NARAYAN SWAMY, GARMISE, ROBERT J, CHOWAN, GAJENDRA SINGH, LEVONS, JAQUAN KALANI, SAXENA, AJAY
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to solid amorphous dispersions comprising Compound (I) having the formula and one or more polymers or to solution formulations comprising Compound (I) and one or more co-solvents and surfactants. The formulations exhibit enhanced stability and bioavailability.