2'3'-cyclic dinucleotides and prodrugs thereof

The present disclosure relates to 2'3' cyclic phosphonate dinucleotides of Formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said com...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BIRKUS, GABRIEL, PAV, ONDREJ, KAISER, MARTIN MAXIMILIAN, BREHOVA, PETRA, SIMAK, ONDREJ, KOSTOV, ONDREJ
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present disclosure relates to 2'3' cyclic phosphonate dinucleotides of Formula (I), their pharmaceutically acceptable salts, their pharmaceutical composition and combinations of said substances and other medicaments or pharmaceuticals. The disclosure also relates to the use of said compounds for the treatment or prevention of diseases or conditions modifiable by STING protein modulation, such as cancer or viral, allergic and inflammatory diseases. In addition, these substances can be used as adjuvants in vaccines.