Method of producing an immunogenic composition

The present invention in particular relates to a method of producing an immunogenic composition exhibiting reduced virucidal activity, as well as to the immunogenic composition and uses thereof, wherein the method in particular comprises the steps of: (a) providing a mixture with a first liquid and...

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Bibliographische Detailangaben
Hauptverfasser: GASSEL, MICHAEL JOHANNES, BROWN, AMANDA, ORVEILLON, FRANCOIS-XAVIER, BAUTISTA, ELIDA, SCHLESINGER, KATHY, WILMES, LEIGH, COONS, MATTHEW, TOEPFER, KATHARINA HEDWIG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The present invention in particular relates to a method of producing an immunogenic composition exhibiting reduced virucidal activity, as well as to the immunogenic composition and uses thereof, wherein the method in particular comprises the steps of: (a) providing a mixture with a first liquid and a recombinant protein, (b) concentrating the recombinant protein in the mixture by removing a portion of the first liquid from the mixture, and (c) processing the solution resulting from step (b) by continuous diafiltration.