HSP90-targeting conjugates and formulations thereof

HSP90-targeting conjugates and formulations thereof

Conjugates of an active agent attached to a targeting moiety, such as an HSP90 binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penet...

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Bibliographische Detailangaben
Hauptverfasser: WOOSTER, RICHARD, KADIYALA, SUDHAKAR, CIPRIANI, TYLER, WHALEN, KERRY, WHITE, BRIAN H, BILODEAU, MARK T, CIRELLO, AMANDA L, MOREAU, BENOIT, QUINN, JAMES M, PERINO, SAMANTHA
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Conjugates of an active agent attached to a targeting moiety, such as an HSP90 binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.