1,3-substituted pyrazole compounds useful for reduction of very long chain fatty acid levels

1,3-substituted pyrazole compounds useful for reduction of very long chain fatty acid levels

Disclosed are chemical entities which are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Formula (I) has the structure, (I), wherein: R1a, R1b, R2, R3, R4a, R4b and Y are as defined herein. These chemical entities are useful for reduction of very long chain fatty aci...

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Hauptverfasser: GU, WENXIN, NANTHAKUMAR, SUGANTHINI S, GALE-DAY, ZACHARY, RONKIN, STEVEN MICHAEL, JACKSON, KATRINA L, MAGAVI, SANJAY SHIVAYOGI, CHARIFSON, PAUL S, SWETT, REBECCA JANE, COURT, JOHN J, TANG, QING, COME, JON H
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed are chemical entities which are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Formula (I) has the structure, (I), wherein: R1a, R1b, R2, R3, R4a, R4b and Y are as defined herein. These chemical entities are useful for reduction of very long chain fatty acid levels. These chemical entities and pharmaceutically acceptable compositions comprising such chemical entities can be useful for treating various diseases, disorders and conditions, such as adrenoleukodystrophy (ALD).