Antibodies to Plasminogen Activator Inhibitor-1 (PAI-1) and uses thereof

Antibodies to Plasminogen Activator Inhibitor-1 (PAI-1) and uses thereof

The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1). The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or f...

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Bibliographische Detailangaben
Hauptverfasser: JANIAK, PHILIP, BAURIN, NICOLAS, LI, HAN, PRITSKER, ALLA, POIRER, BRUNO, RAK, ALEXEY, GRAIHE, PATRICK, DAVEU, CYRIL, KOMINOS, DOROTHEA, MATHIEU, MAGALI, DUFFIEUX, FRANCIS, MORGAN, CHRIS
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1). The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.