Carboxylic acid derivatives

The present invention pertains to a compound that has an excellent retinoic acid receptor-related orphan receptor [gamma] t inhibitory effect, or a pharmaceutically acceptable salt thereof. Provided is a compound represented by general formula (I), or a pharmaceutically acceptable salt thereof. (In...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GOTANDA, KENTOKU, ISOBE, TAKASHI, SASAKI, JUNKO, NOGUCHI, TETSUJI, YOSHINO, TOSHIHARU, RAMADASS, VENKATARAMANAN, GOTO, TAIJI, TORIHATA, MUNEFUMI, NAGAMOCHI, MASATOSHI
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention pertains to a compound that has an excellent retinoic acid receptor-related orphan receptor [gamma] t inhibitory effect, or a pharmaceutically acceptable salt thereof. Provided is a compound represented by general formula (I), or a pharmaceutically acceptable salt thereof. (In the formula, R1 is a C1-C6 alkyl group, a C3-C6 cycloalkyl group, or a phenyl group. R2 is a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like. R3 is a hydrogen atom, a C2-C7 carboxyalkyl group, or a hydroxyl group. R4 is a halogen atom or a C1-C6 alkyl group. R5 is a hydrogen atom or a C1-C6 alkyl group. R6 is a hydrogen atom, a halogen atom, or a C1-C6 alkyl group. R7 is a hydrogen atom, a halogen atom, or the like. R8 is a hydroxyl group, a C1-C6 alkoxy group, a mono-C1-C6 alkylamino group, or the like. L is a single bond, a methylene group, or an oxygen atom. E is a phenylene group optionally substituted independently with one or two groups selected from halogen atoms, C1-C6 alkyl groups, and C1-C