Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof

The present invention relates to modified insulin analogs and blood glucose regulating proteins with improved activity profiles, methods of preparing these molecules, pharmaceutical formulations thereof, as well as their use in therapy. Further the invention relates to methods for inhibiting proteas...

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Bibliographische Detailangaben
Hauptverfasser:	KORN, MARCUS HERMANN, WENDRICH, THOMAS, SEIPKE, GERHARD, STILLGER, THOMAS, HABERMANN, PAUL, SCHMIDT, RONALD, TENNAGELS, NORBERT, WERNER, ULRICH
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to modified insulin analogs and blood glucose regulating proteins with improved activity profiles, methods of preparing these molecules, pharmaceutical formulations thereof, as well as their use in therapy. Further the invention relates to methods for inhibiting protease degradation in serum and/or increasing serum stability of a protein.