Modified interleukin 21 receptor proteins

Disclosed herein are modified interleukin 21 receptor extracellular domain (IL21R ECD) proteins comprising a modification selected from: one or more amino acid substitutions at or within 4 amino acid residues of the tryptophan at position 148 of the amino acid sequence of SEQ ID NO:1, an insertion o...

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Bibliographische Detailangaben
Hauptverfasser:	OLLAND, STEPHANE, KRIZ, RONALD WILLIAM, SOMERS, WILLIAM STUART, STAHL, MARK LLOYD, FEYFANT, ERIC, LISOWSKI, MICHELLE MALOUIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are modified interleukin 21 receptor extracellular domain (IL21R ECD) proteins comprising a modification selected from: one or more amino acid substitutions at or within 4 amino acid residues of the tryptophan at position 148 of the amino acid sequence of SEQ ID NO:1, an insertion of one or more amino acids at position 148 of the amino acid sequence of SEQ ID NO:1, or deletion of the tryptophan at position 148 of the amino acid sequence of SEQ ID NO:1. Additional substitutions are also contemplated. Also disclosed are fusion proteins comprising the modified IL21R ECD proteins, pharmaceutical compositions comprising the modified IL21R ECD proteins and fusion proteins, and methods of treatment and uses relating to the modified IL21R ECD proteins and fusion proteins.