Pyrazolopyrimidine prodrugs and methods of use

The preset invention relates to new prodrugs of pyrazolopyrimidines that have certain biological activities in inhibition of CK2, exhibiting improved solubility, stability, bioavailability, and pharmacokinetic properties. A pharmaceutical composition and method for treating proliferative disorders s...

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Bibliographische Detailangaben
Hauptverfasser:	RYCKMAN, DAVID M, HADDACH, MUSTAPHA, RAFFAELE, NICHOLAS B
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The preset invention relates to new prodrugs of pyrazolopyrimidines that have certain biological activities in inhibition of CK2, exhibiting improved solubility, stability, bioavailability, and pharmacokinetic properties. A pharmaceutical composition and method for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammatory condition, infectious disorder, pain, immunological disorder, or a neurodegenerative disorder using the prodrugs of the invention are also provided.