2'-branched nucleosides for treatment of viral infections

The present invention provides a compound of formula A: or a pharmaceically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever v...

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Bibliographische Detailangaben
Hauptverfasser:	FENAUX, MARTIJN, MAO, LIANG, ANANDAN, SAMPATH-KUMAR, AULAKH, VIRENDER SINGH, YOKOKAWA, FUMIAKI, SAUNDERS, OLIVER, LIN, XIAODONG, SWEENEY, ZACHARY KEVIN, ZHONG, WEIDONG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention provides a compound of formula A: or a pharmaceically acceptable salt thereof, wherein B, Q, R1, R5, R6, R7, R8 and Z are defined herein, which is a 2'-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.