Factor VIIa complex using an immunoglobulin fragment

Disclosed are a blood coagulation factor complex, FacVIIa, enhanced in vivo persistency and stability, in which FacVIIa, a non-peptidyl polymer and an immunoglobulin Fc region are bonded by covalent bonds, and the uses thereof. The FavVIIa complex guarantees the in vivo activity of FacVIIa in a rela...

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Bibliographische Detailangaben
Hauptverfasser:	IM, DAE-SEONG, HONG, SUNG-KAP, KWON, SEANG, LIM, SUNG-IN, KIM, CHANG-HWAN, SONG, DAE-HAE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are a blood coagulation factor complex, FacVIIa, enhanced in vivo persistency and stability, in which FacVIIa, a non-peptidyl polymer and an immunoglobulin Fc region are bonded by covalent bonds, and the uses thereof. The FavVIIa complex guarantees the in vivo activity of FacVIIa in a relatively high level and significantly enhances the serum half-life of FacVIIa, so that it is useful for developing long-acting FacVIIa formulations which can improve the compliance of role behavior of patients treated with this complex.