Small inference RNA molecule of indoleamine 2,3-dioxygenase and applications thereof

The present invention relates to a siRNA molecule for inhibiting Indoleamine 2, 3-dioxygenase, comprising a target sequence selected from Indoleamine 2, 3-dioxygenase gene. The present invention also relates to a pharmaceutical composition comprising said siRNA molecule and applications thereof. Sai...

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Bibliographische Detailangaben
Hauptverfasser:	YEN, MENGI, LIN, CHIN, HUANG, TZU-TING, LAI, MING-DERG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a siRNA molecule for inhibiting Indoleamine 2, 3-dioxygenase, comprising a target sequence selected from Indoleamine 2, 3-dioxygenase gene. The present invention also relates to a pharmaceutical composition comprising said siRNA molecule and applications thereof. Said siRNA molecule reduces the expression of Indoleamine 2, 3-dioxygenase to activate CD8+ T cells in lymph nodes to kill tumor cells, thereby enhancing immune system against cancer. This invention is the first discovery that a siRNA molecule against Thrombospondin-1 can delay tumor progression.