Tricyclic compounds for the treatment of inflammatory disorders

Tricyclic compounds for the treatment of inflammatory disorders

The present invention provides compounds represented by general formula 1: wherein, R1 R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined in the specification, in all its stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and its pharmaceutically acceptable...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SUTHAR, ASHISH, BHEDI, DILIP NARAYANRAO, VISHWAKARMA, RAM ASREY, DEKA, VAISHALI, PARIKH, SAPNA, MORE, DATTATRAY MARUTI, TANNU, ADITI AMOL, RAMALINGAM, MANIVANNAN, DALAL, RODA
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides compounds represented by general formula 1: wherein, R1 R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and X are as defined in the specification, in all its stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable polymorphs and prodrugs. These compounds are useful for treatment of inflammatory disorders including those caused by elevated levels of proinflammatory cytokines such as Tumor Necrosis Factor (TNF- and/or interleukins (IL-1 , IL-6, IL-8). The invention also relates to processes for the manufacture of compounds of formula 1 and pharmaceutical compositions containing them.