Non steroidal glucocorticoid receptor modulators
The present invention relates to compounds having general formula I, or a pharmaceutically acceptable salt thereof. In this formula R1 is H or (1-4C)alkyl; R2 is -C(O)R15 or -S(O)2R15; R3 is H, (1-4C)alkyl or -OR16; R4 is H, (1-4C)alkyl or -OR16; R6 is H or -C(H)NOR16; R7 is H or halogen, cyano; (1-...
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Zusammenfassung: | The present invention relates to compounds having general formula I, or a pharmaceutically acceptable salt thereof. In this formula R1 is H or (1-4C)alkyl; R2 is -C(O)R15 or -S(O)2R15; R3 is H, (1-4C)alkyl or -OR16; R4 is H, (1-4C)alkyl or -OR16; R6 is H or -C(H)NOR16; R7 is H or halogen, cyano; (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl, all three optionally substituted with OH, halogen or NH2; -C(H)NOR16, -OR16, -C(O)R16, or -C(O)OR16; R8 is H, cyano, halogen, nitro; (1-6C) alkyl, (2-6C)alkenyl, (2-6C)alkynyl or -O(1-6C)alkyl, all optionally substituted with amino, hydroxyl or halogen; (hetero)aryl, optionally substituted with cyano, halogen, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkoxy(1-4C)alkyl; -C(O)R18, -C(O)OR19, -C(O)NHR17, -NHC(O)R20, -C(1-4C)alkylNOR21; -C(H)NOR16, or -NHS(O)2R21; R9 is H, halogen, cyano or (1-4C)alkyl optionally substituted with halogen; R10 is H or (1-4C)alkyl; R11 is H; R12 is H, cyano or (1-4C)alkyl; R13 is H, (1-4C)alkyl, halogen or formyl; R14 is H, halogen, cyano, (1-4C)alkyl, ( |
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