Non steroidal glucocorticoid receptor modulators

The present invention relates to compounds having general formula I, or a pharmaceutically acceptable salt thereof. In this formula R1 is H or (1-4C)alkyl; R2 is -C(O)R15 or -S(O)2R15; R3 is H, (1-4C)alkyl or -OR16; R4 is H, (1-4C)alkyl or -OR16; R6 is H or -C(H)NOR16; R7 is H or halogen, cyano; (1-...

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Hauptverfasser: BUIJSMAN, ROGIER CHRISTIAN, DE MAN, ADRIANUS PETRUS ANTONIUS, HERMKENS, PEDRO HAROLD HAN, JANS, CHRISTAN GERARDUS JOHANNES MARIA, LUSHER, SCOTT JAMES, CONTI, PAOLO GIOVANNI MARTINO, PLATE, RALF, DOKTER, WILLEM HENDRIK ABRAHAM, ZAMAN, GUIDO JENNY RUDOLF
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates to compounds having general formula I, or a pharmaceutically acceptable salt thereof. In this formula R1 is H or (1-4C)alkyl; R2 is -C(O)R15 or -S(O)2R15; R3 is H, (1-4C)alkyl or -OR16; R4 is H, (1-4C)alkyl or -OR16; R6 is H or -C(H)NOR16; R7 is H or halogen, cyano; (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl, all three optionally substituted with OH, halogen or NH2; -C(H)NOR16, -OR16, -C(O)R16, or -C(O)OR16; R8 is H, cyano, halogen, nitro; (1-6C) alkyl, (2-6C)alkenyl, (2-6C)alkynyl or -O(1-6C)alkyl, all optionally substituted with amino, hydroxyl or halogen; (hetero)aryl, optionally substituted with cyano, halogen, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkoxy(1-4C)alkyl; -C(O)R18, -C(O)OR19, -C(O)NHR17, -NHC(O)R20, -C(1-4C)alkylNOR21; -C(H)NOR16, or -NHS(O)2R21; R9 is H, halogen, cyano or (1-4C)alkyl optionally substituted with halogen; R10 is H or (1-4C)alkyl; R11 is H; R12 is H, cyano or (1-4C)alkyl; R13 is H, (1-4C)alkyl, halogen or formyl; R14 is H, halogen, cyano, (1-4C)alkyl, (