Process for preparing diphenylazetidinone derivatives

In the process for preparing diphenylazetidinone derivatives of the formula(I) or forms protected in the substituents X, R1 and/or R2, in which the symbols, substituents and indices have the following meaning, X=H, OH; R1=OH, OCH3; R2=F, CH2CH3, CH2NHR4; R3=H, F; R4=H, CO-(CH2-)Nco-R5, CO-(CH2-)Nnhr...

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Bibliographische Detailangaben
Hauptverfasser:	JUNKER, BERND, WOLLMANN, THEODOR ANDREAS, JENDRALLA, HEINER, BILLEN, GUENTER, FRICK, WENDELIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	In the process for preparing diphenylazetidinone derivatives of the formula(I) or forms protected in the substituents X, R1 and/or R2, in which the symbols, substituents and indices have the following meaning, X=H, OH; R1=OH, OCH3; R2=F, CH2CH3, CH2NHR4; R3=H, F; R4=H, CO-(CH2-)Nco-R5, CO-(CH2-)Nnhr6; n = integers from 4 to 16; R5=OH, NH-CH2-[CH(OH)-]Mch2oh; R6=H, CO-[CH(OH)-]Mch2oh and m=integers from 1 to 5 compounds of the formula (II), which are novel, , with the meaning of Y=H, H; H, OH; H, Oac; H, Osi(alkyl)o(aryl)p with o, p=0, 1, 2 or 3 and o+p=3; H, OTHP; H, OC(aryl)3; H, OCH2Oalkyl; H, OCH(Oalkyl)CH3; H,Oalkyl; H, OCH2aryl; Oalkyl, Oalkyl; cyclic ketal such as O-(CH2-)q-O with q=2 or 3 are reacted with imines of the formula(III), with R7=R1 and additionally O-protective group and R8=, for example, R2. Intermediates occurring in this reaction are novel amino amides of the formula(IV)