Antibodies against interleukin-1 receptor and uses thereof

This invention relates to an antibody binding to human IL-1R and inhibiting the binding of human IL-1 to IL-1R, characterized in that said antibody comprises variable heavy chain region CDR1(aa 45-54), CDR2(aa 69-84) and CDR3(aa 117-123) containing SEQ ID NO:1 of CDRs, and variable light chain regio...

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Bibliographische Detailangaben
Hauptverfasser:	BARTKE, ILSE, CARR, FRANCIS, EUGUI, ELSIE M, FERTIG, GEORG, TRUITT, THERESA PATRICIA, CHIZZONITE, RICHARD ANTHONY, RUEGER, PETRA, SCHUMACHER, RALF, LANZENDOERFER, MARTIN, HAMILTON, ANITA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention relates to an antibody binding to human IL-1R and inhibiting the binding of human IL-1 to IL-1R, characterized in that said antibody comprises variable heavy chain region CDR1(aa 45-54), CDR2(aa 69-84) and CDR3(aa 117-123) containing SEQ ID NO:1 of CDRs, and variable light chain region CDR1 (aa 43-57), CDR2 (aa 73-79) and CDR3 (aa 112-120) containing SEQ ID NO.2, or is a chimeric, humanized or T cell epitope depleted antibody variant or a fragment of said antibody showing an IC50 value of 35 pM or lower for the inhibition of IL-1 mediated secretion of IL-8 in human fibroblast cells like MRC5 (ATCC CCL 171) has advantageous properties for the treatment of inflammatory diseases.