2-pirazolin-5-on terkipleri

(I) yapisal formülünü haiz kimyasal terkipler ve fizyolojik olarak kabul edilebilir tuzlari serin/treonin ve tirosin kinaz etkinliginin engelleyicileridir.Etkinlikleri bu kimyasal terkipler tarafindan engellenen birçok tirosin kinaz anjiyogenik süreçlere katilir. Böylece bu kimyasal terkipler anjiyogenezin veya endotelyal hücre çogalmasinin etken oldugu hastalik durumlarini iyilestirebilir.Bu terkipler kanser ve hiperproliferatif bozukluklarin da tedavisinde kullanilabilir. Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.