MEK enzimleri inhibitörleri olarak kinolin türevleri

Mevcut bulus belli kinolin türevlerinin ilaçlarin hazirlanmasinda, özellikle özel kinaz enzimlerinin, özellikle MEK enzimlerinin, inhibitörleri olarak kullanimi ile ve ayni zamanda yeni kinolin türevleri ile ilgilidir. Bulusun diger yönleri bahsedilen bilesiklerin kullanilmasiyla kanser gibi ilerleyen hastalik tedavisi için farmasötik bilesimleri ve yöntemleri kapsar. A compound formula (I)or a pharmaceutically acceptable salt thereof, for use in the manufacture of a medicament for inhibition of MEK in a mammal with a MEK mediated disease wherein: n is 0-1; Y is selected from -NH-, -O-, -S-, or -NR - where R is alkyl of 1-6 carbon atoms R is cycloalkyl of 3 to 7 carbon atoms, which may be optionally substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be substituted with one, two or three specified substitutents; or R is a group -R -X-R were R is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is an optionally pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified substitutents, X is selected from CH2, -NH-, -O-, -S- or -NR - where R is alkyl of 1-6 carbon atoms, and R is a group (CH2)mR where m is 0, or an integer of from 1-3 and R is an optionally substituted aryl or optionally substituted cycloalkyl ring of up to 10 carbon atoms, or R is a heterocyclic ring containing 1 or 2 oxygen atoms and optionally one or more substitutents; and R , R , R and R are each independently selected from hydrogen or various specified organic groups. Novel compounds are also described and claimed.