P38 kinaz inhibitörleri olarak sübstitüe edilmiş pirazoller

P38 kinaz kaynakli bozukluklarin tedavisinde kullanilmak üzere pirazol türevlerinin bir sinifi tarif edilmektedir. Özellikle tercih edilen bilesikler formül (IA) ile tanimlanmaktadir. A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particu...

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Hauptverfasser:	HE HUANG, LIFENG GENG, JOHN JEFFREY TALLEY, SHAUN RAJ SELNESS, DANIEL L. FLYNN, SUSAN J. HARTMANN, THAO D. PERRY, RICHARD M. WEIER, MICHAEL S. SOUTH, CATHLEEN E. HANAU, MICHAEL A. STEALEY, FRANCIS J. KOSZYK, MICHAEL L. VAZQUEZ, RAJESH DEVRAJ, PAUL W. COLLINS, SHASHIDHAR N. RAO, YI YU, MICHAEL HEPPERLE, ISH KHANNA, JOYCE Z. CRICH, GUNNAR J. HANSON, XIANGDONG XU, MATTHEW J. GRANETO, MICHAEL CLARE, SHUYUAN LIAO, SUZANNE METZ, RICHARD A. PARTIS, ASHOK ANANTANARAYAN
Format:	Patent
Sprache:	tur
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	P38 kinaz kaynakli bozukluklarin tedavisinde kullanilmak üzere pirazol türevlerinin bir sinifi tarif edilmektedir. Özellikle tercih edilen bilesikler formül (IA) ile tanimlanmaktadir. A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R , R , R and R are as described in the specification.