Donepezil hidroklorid polimorflari ve üretim prosesleri

Donepezil hidroklorid, 1-benzil-4-(5,6-dimetoksi-1-indanon)-2-y1) metilpiperidin hidroklorid burada, farmasötik kullanimda isiya ve neme karsi kararli olan dört polimorf seklinde sunulmustur. Bunlar sinai olarak üretilebilirler. X-isini kirinim sablonunda doruklar ve potasyum bromid içinde kizilötes...

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Bibliographische Detailangaben
Hauptverfasser:	AKIYO OHTSUKA, HIDEAKI WATANABE, AKIO IMAI, KAJIMA TAKASHI, YASUSHI ISHIHAMA, TOMOHIDE TANAKA, YUKIO NARABU
Format:	Patent
Sprache:	tur
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Donepezil hidroklorid, 1-benzil-4-(5,6-dimetoksi-1-indanon)-2-y1) metilpiperidin hidroklorid burada, farmasötik kullanimda isiya ve neme karsi kararli olan dört polimorf seklinde sunulmustur. Bunlar sinai olarak üretilebilirler. X-isini kirinim sablonunda doruklar ve potasyum bromid içinde kizilötesi emilme tayfinda emilme doruklari ile belirlenirler. Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.