Ikameli 5-hidroksi-okzazolidin-4-on'un hazirlanmasi islemi

Genel formül II'nin bir bileseninin sentezi için bir islemdir; formül: R ve R 'ün herbiri birbirinden bagimsiz olarak hidrojen veya Ci-C4 alkaldir; A, halojen, Ci-C10 hidrokarbil, -S (Ci-C10 hidrokarbil), -SO(Ci-C10 hidrokarbil),-SO2(Ci-C10 hidrokarbil), siyano, nitro, SCN, SIRC3 (herbir Rc, C1-C4 alkil veya fenil'dir), COR7, CR7 NOR8, NHOH, ONR7 RR8,SF5, COOR7R8, SF5, COOR7, SO2NR7 R8, OR9 VEYA NR10R11 arasindan seçilen bir veya daha fazla ikame edici ile istege bagli olarak ikame edilmis bir aromatik veya heteroaromatik halka sistemidir; bu sistemde nitrojen atomu dördüllenebilir veya oksitlenebilir; alternatif olarak, A grubunun herhangi iki ikame edicisi, birbirine kaynamis 5 veya 6 üyeli doymus veya kismen doymus karboksilik veya heterosilik halka olusturmak üzere birlesebilir. A process for the synthesis of a compound of general formula II: II wherein: R2 and R3 are each independently hydrogen or C1-C4 alkyl; A is an aromatic or heteroaromatic ring system optionally substituted with one or more substituents as defined herein; and in which any ring nitrogen atom may be quaternised or oxidised; alternatively, any two substituents of the group A may combine to form a fused 5- or 6-membered saturated or partially saturated carbocyclic or heterocyclic ring in which any carbon or quaternised nitrogen atom may be substituted with any of the groups defined herein for A or in which a ring carbon atom may be oxidised; the process comprising cyclising a compound of general formula VII: VII wherein A, R2 and R3 are as defined for general formula II, R20 is hydrogen, benzyl or benzyl substituted with up to five substituents selected from halo, C1-C6 alkyl, O(C1-C6 alkyl) or nitro and R21 is C1-C8 alkyl, benzyl or benzyl substituted with up to five of the substituents mentioned above for R20.