COMPLEXES D'INCLUSION DE SELS ARYL-HETEROCYCLIQUES

L'INVENTION CONCERNE DES COMPOSITIONS COMPRENANT UN SEL PHARMACEUTIQUEMENT ACCEPTABLE D'UN COMPOSE ARYLHETEROCYCLIQUE, TEL QUE LA ZIPRASIDONE, DANS UNE CYCLODEXTRINE. LES CYCLODEXTRINES PREFEREES CONSISTENT EN SBECD ET HPBCD ET LES SELS PREFEREES COMPRENNENT LE MESYLATE, L'ESYLATE, LE BESYLATE, LE TARTRATE, LE NAPSYLATE ET LE TOSYLATE. APPLICATION : PREPARATION DE COMPOSITIONS PHARMACEUTIQUES A HYDROSOLUBILITE AMELIOREE. Compositions of matter comprising a phamaceutically acceptable salt of an arylheterocyclic compound, such as ziprasidone, in a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry inclusion complex or an aqueous solution. The salt/cyclodextrin inclusion complex preferably provides an amount of ziprasidone of at least 2.5 mgA/ml when the complex is dissolved in water at 40% w/v. A variety of ziprasidone salts are preferred, including the mesylate, esylate, besylate, tartrate, napsylate, and tosylate.