COMPOSES NOUVEAUX INHIBITEURS DE BCAT, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS LES CONTENANT

L'INVENTION CONCERNE DES COMPOSES DE FORMULE (I) : DANS LAQUELLE R1, R2, R3, R4 R5 ET Ar REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION AINSI QUE DES COMPOSITIONS LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS, COMME INHIBITEURS...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	BORA KEENAN MARTIN, LEI HUANYSHU, RAFFERTY MICHAEL FRANCIS, WUSTROW DAVID JUERGEN, MORELAND DAVID WINSLOW, RYDER TODD ROBERT, HU LAIN-YEN, KESTEN SUZANNE ROSS, SCHOLTEN JEFFREY DAVID
Format:	Patent
Sprache:	fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	L'INVENTION CONCERNE DES COMPOSES DE FORMULE (I) : DANS LAQUELLE R1, R2, R3, R4 R5 ET Ar REPRESENTENT DIVERS RADICAUX. ELLE CONCERNE EGALEMENT UN PROCEDE POUR LEUR PREPARATION AINSI QUE DES COMPOSITIONS LES CONTENANT. APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS, COMME INHIBITEURS DE BCAT, POUR LE TRAITEMENT OU LA PREVENTION DE DIVERSES MALADIES. The invention relates to BCAT inhibitor compounds of formula (I) and use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.