TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS

TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS

Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders...

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Bibliographische Detailangaben
Hauptverfasser: MA VU VAN, YUAN CHESTER CHENGUANG, GORE VIJAY KESHAV, CHEN JIAN.J, BISWAS KAUSTAV, LIU QINGYIAN, HARRIED SCOTT, ZHONG WENGE, BROWN JAMES, MONENSCHEIN HOLGER, ST JEAN DAVID J JR, NGUYEN THOMAS T, HORNE DANIEL B, KALLER MATTHEW R
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have a structure where the definitions of the variables are provided herein.