LIVE, ATTENTUATED RESPIRATORY SYNCYTIAL VIRUS

The present invention features live, attenuated respiratory syncytial viruses (RSV) useful as vaccines against RSV infection and/or the development of severe RSV-associated illnesses. The disclosed viruses are attenuated to the extent of being nonpathogenic when administered to a subject but substan...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YAGODICH MARY K, LIANG XIAOPING, CITRON MICHAEL P, DISTEFANO DANIEL J, KRAH DAVID L
Format: Patent
Sprache:eng ; fre
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Beschreibung
Zusammenfassung:The present invention features live, attenuated respiratory syncytial viruses (RSV) useful as vaccines against RSV infection and/or the development of severe RSV-associated illnesses. The disclosed viruses are attenuated to the extent of being nonpathogenic when administered to a subject but substantially retain the antigenic and immunogenic properties of wild-type RSV.