METHOD FOR PREPARING DERIVATIVES OF CEPHALOSPORIN

METHOD FOR PREPARING DERIVATIVES OF CEPHALOSPORIN

New cephalosporins of the formula: (I) in which n=0 or 1, R1 is a radical of the formula: (II) [in which R4 is a protective radical and R5 is hydrogen, alkyl, vinyl, cyanomethyl or a protective radical], or R1 is a protective radical and R2 is a protective radical or an enzymatically removable radic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PER LE RUA,FR, KLOD MUTONNE,FR, DANIEL FARZH,FR, ZHAN-FRANSUA PEJRONEL,FR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:New cephalosporins of the formula: (I) in which n=0 or 1, R1 is a radical of the formula: (II) [in which R4 is a protective radical and R5 is hydrogen, alkyl, vinyl, cyanomethyl or a protective radical], or R1 is a protective radical and R2 is a protective radical or an enzymatically removable radical, or R1 is an acyl radical which may be substituted in various ways and R2 is a protective radical, in the 3-oxoethyl-bicyclooct-2-ene or -bicyclooct-3-ene or 3-oxoethylidene-bicyclooctane form if n=0, and in the 3-oxoethyl-bicyclooct-2-ene or 3-oxoethylidene-bicyclooctane form if n=1, are useful as intermediates for the preparation of 3-thiovinyl-cephalosporins useful as antibacterial agents.