PROCESS FOR PRODUCING PROSTANE DERIVATIVES OR THEIR SALTS
Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched a...
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| creator | VERNER SKUBALLA,DE BERND RADYUKHEL,DE GERDA MANNESMANN,DE VOLFGANG LOZERT,DE KHELMUT FORBRYUGGEN,DE OLAF LOGE,DE BERND MYULLER,DE |
| description | Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is -CH2-CH2-, cis-CH=CH-, trans-CH=CH- or -C 3BOND C-, W is free or functionally modified hydroxymethylene or free or functionally modified wherein the OH-group can be in the alpha - or beta -position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases. |
| format | Patent |
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BERND MYULLER,DE</creatorcontrib><description>Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is -CH2-CH2-, cis-CH=CH-, trans-CH=CH- or -C 3BOND C-, W is free or functionally modified hydroxymethylene or free or functionally modified wherein the OH-group can be in the alpha - or beta -position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1982</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820423&DB=EPODOC&CC=SU&NR=923365A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19820423&DB=EPODOC&CC=SU&NR=923365A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VERNER SKUBALLA,DE</creatorcontrib><creatorcontrib>BERND RADYUKHEL,DE</creatorcontrib><creatorcontrib>GERDA MANNESMANN,DE</creatorcontrib><creatorcontrib>VOLFGANG LOZERT,DE</creatorcontrib><creatorcontrib>KHELMUT FORBRYUGGEN,DE</creatorcontrib><creatorcontrib>OLAF LOGE,DE</creatorcontrib><creatorcontrib>BERND MYULLER,DE</creatorcontrib><title>PROCESS FOR PRODUCING PROSTANE DERIVATIVES OR THEIR SALTS</title><description>Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is -CH2-CH2-, cis-CH=CH-, trans-CH=CH- or -C 3BOND C-, W is free or functionally modified hydroxymethylene or free or functionally modified wherein the OH-group can be in the alpha - or beta -position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1982</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMCPJ3dg0OVnDzD1IAsl1CnT393EGs4BBHP1cFF9cgzzDHEM8w12AFoIoQD1fPIIVgR5-QYB4G1rTEnOJUXijNzSDv5hri7KGbWpAfn1pckJicmpdaEh8camlkbGxm6mhsTFgFABj9KG8</recordid><startdate>19820423</startdate><enddate>19820423</enddate><creator>VERNER SKUBALLA,DE</creator><creator>BERND RADYUKHEL,DE</creator><creator>GERDA MANNESMANN,DE</creator><creator>VOLFGANG LOZERT,DE</creator><creator>KHELMUT FORBRYUGGEN,DE</creator><creator>OLAF LOGE,DE</creator><creator>BERND MYULLER,DE</creator><scope>EVB</scope></search><sort><creationdate>19820423</creationdate><title>PROCESS FOR PRODUCING PROSTANE DERIVATIVES OR THEIR SALTS</title><author>VERNER SKUBALLA,DE ; BERND RADYUKHEL,DE ; GERDA MANNESMANN,DE ; VOLFGANG LOZERT,DE ; KHELMUT FORBRYUGGEN,DE ; OLAF LOGE,DE ; BERND MYULLER,DE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SU923365A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1982</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>VERNER SKUBALLA,DE</creatorcontrib><creatorcontrib>BERND RADYUKHEL,DE</creatorcontrib><creatorcontrib>GERDA MANNESMANN,DE</creatorcontrib><creatorcontrib>VOLFGANG LOZERT,DE</creatorcontrib><creatorcontrib>KHELMUT FORBRYUGGEN,DE</creatorcontrib><creatorcontrib>OLAF LOGE,DE</creatorcontrib><creatorcontrib>BERND MYULLER,DE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VERNER SKUBALLA,DE</au><au>BERND RADYUKHEL,DE</au><au>GERDA MANNESMANN,DE</au><au>VOLFGANG LOZERT,DE</au><au>KHELMUT FORBRYUGGEN,DE</au><au>OLAF LOGE,DE</au><au>BERND MYULLER,DE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PRODUCING PROSTANE DERIVATIVES OR THEIR SALTS</title><date>1982-04-23</date><risdate>1982</risdate><abstract>Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is -CH2-CH2-, cis-CH=CH-, trans-CH=CH- or -C 3BOND C-, W is free or functionally modified hydroxymethylene or free or functionally modified wherein the OH-group can be in the alpha - or beta -position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR PRODUCING PROSTANE DERIVATIVES OR THEIR SALTS |
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