PROCESS FOR PRODUCING PROSTANE DERIVATIVES OR THEIR SALTS

Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	VERNER SKUBALLA,DE, BERND RADYUKHEL,DE, GERDA MANNESMANN,DE, VOLFGANG LOZERT,DE, KHELMUT FORBRYUGGEN,DE, OLAF LOGE,DE, BERND MYULLER,DE
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula wherein R1 is (a) OR3, wherein R3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR4 wherein R4 is an acid residue; B is straight-chain or branched alkylene of 2-10 carbon atoms; A is -CH2-CH2-, cis-CH=CH-, trans-CH=CH- or -C 3BOND C-, W is free or functionally modified hydroxymethylene or free or functionally modified wherein the OH-group can be in the alpha - or beta -position; D and E together are a direct bond; or D is straight-chain or branched alkylene of 1-5 carbon atoms; and E is oxygen or sulfur or a direct bond, R2 is alkyl, cycloalkyl, optionally substituted aryl or a heterocyclic group; and R5 is free or functionally modified hydroxy; and when R3 is hydrogen, the salts thereof with physiologically compatible bases.