METHOD OF PREPARING ANTHRACYCLINES

Daunorubicin (also known as daunomycin) derivatives of the formula I wherein X is and R is -COCF3 or H which are prepared by hydrogenating 9-desacetyl-9-keto-N-trifluoroacetyldaunorubicin, an unexpectedly stable key-intermediate which is itself a new compound, are useful in treating certain mammalia...

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Hauptverfasser: FEDERIKO ARKAMONE,IT, SERDZHO PENKO,IT, FRANCHESKO ANDZHELUCHCHI,IT
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creator FEDERIKO ARKAMONE,IT
SERDZHO PENKO,IT
FRANCHESKO ANDZHELUCHCHI,IT
description Daunorubicin (also known as daunomycin) derivatives of the formula I wherein X is and R is -COCF3 or H which are prepared by hydrogenating 9-desacetyl-9-keto-N-trifluoroacetyldaunorubicin, an unexpectedly stable key-intermediate which is itself a new compound, are useful in treating certain mammalian tumors.
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subjects CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
title METHOD OF PREPARING ANTHRACYCLINES
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