METHOD OF PREPARING ANTHRACYCLINES

METHOD OF PREPARING ANTHRACYCLINES

Daunorubicin (also known as daunomycin) derivatives of the formula I wherein X is and R is -COCF3 or H which are prepared by hydrogenating 9-desacetyl-9-keto-N-trifluoroacetyldaunorubicin, an unexpectedly stable key-intermediate which is itself a new compound, are useful in treating certain mammalia...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FEDERIKO ARKAMONE,IT, SERDZHO PENKO,IT, FRANCHESKO ANDZHELUCHCHI,IT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:Daunorubicin (also known as daunomycin) derivatives of the formula I wherein X is and R is -COCF3 or H which are prepared by hydrogenating 9-desacetyl-9-keto-N-trifluoroacetyldaunorubicin, an unexpectedly stable key-intermediate which is itself a new compound, are useful in treating certain mammalian tumors.