METHOD OF OBTAINING DAHUNORUBICIN DERIVATIVES OR SALTS THEREOF

METHOD OF OBTAINING DAHUNORUBICIN DERIVATIVES OR SALTS THEREOF

Daunorubicin derivatives of the formula: wherein R1 represents a group of the formula: in which (i) X1 and X2 both represent oxygen or both represent sulphur and the symbols R3 each represent alkyl of 1 through 4 carbon atoms, phenyl or phenyl substituted in the para-position by methyl, methoxy or m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHERAR PONSINE,FR, DANIEL FARZH,FR, ZHAN-BERNAR DYUSEP,FR, DANIEL REJSDORF,FR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:Daunorubicin derivatives of the formula: wherein R1 represents a group of the formula: in which (i) X1 and X2 both represent oxygen or both represent sulphur and the symbols R3 each represent alkyl of 1 through 4 carbon atoms, phenyl or phenyl substituted in the para-position by methyl, methoxy or methylthio, or together form an alkylene radical of 2 through 4 carbon atoms, or (ii) one of X1 and X2 represents oxygen and the other represents sulphur and the symbols R3 together form an alkylene radical of 2 through 4 carbon atoms, and R4 represents hydrogen, alkyl of 1 through 4 carbon atoms or phenyl, and R2 represents hydrogen or trifluoroacetyl, are new compounds possessing anti-tumour properties.