METHOD OF OBTAINING ANALOGUE OF DAUNOMYCIN OR ITS CHLORINE HYDRATE

METHOD OF OBTAINING ANALOGUE OF DAUNOMYCIN OR ITS CHLORINE HYDRATE

Daunomycin analogues of the formula: (I) wherein when each R1 is hydrogen, each R is hydrogen, chlorine, bromine, methyl or methoxy and when each R1 is chlorine, bromine or methyl, each R is hydrogen, are useful in treating various mammalian tumors and are prepared by reacting a daunomycinone deriva...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LUIDZHI BERNARDI,IT, FEDERIKO ARKAMONE,IT, BYANKO PATELLI,IT, AURELIOMARKO,IT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Beschreibung
Zusammenfassung:Daunomycin analogues of the formula: (I) wherein when each R1 is hydrogen, each R is hydrogen, chlorine, bromine, methyl or methoxy and when each R1 is chlorine, bromine or methyl, each R is hydrogen, are useful in treating various mammalian tumors and are prepared by reacting a daunomycinone derivative of the formula: (II) wherein R and R1 are as defined above with 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy- alpha -L-lyxopyranose in an inert anhydrous organic solvent in the presence of a catalyst and a hydrogen chloride acceptor.