METHOD OF OBTAINING INDOLE-QUINOLYSIDINE DERIVATIVES OR THEIR SALTS OR OPTICALLY ACTIVE ISOMER

The invention relates to new indolo-quinolizidine derivatives of the general formula (I) or salts or optically active isomers thereof, (I) wherein R stands for an alkyl group, and pharmaceutical compositions containing the same, as well as to a process for the preparation thereof. The new compounds...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: EGON KARPATI,HU, LASLO SPORNI,HU, LAJOSH SABO,HU, CHABA SANTAJ,HU, DERD KALAUSH,HU
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention relates to new indolo-quinolizidine derivatives of the general formula (I) or salts or optically active isomers thereof, (I) wherein R stands for an alkyl group, and pharmaceutical compositions containing the same, as well as to a process for the preparation thereof. The new compounds according to the invention possess vasodilatating and hypotensive effects and can be used in the therapy as medicines. The new compounds according to the invention are completely devoid of harmful side-effects The compounds of the general formula (I), or their salts or optically active isomers, respectively, are prepared according to the invention as follows: a compound of the general formula (IV), (IV) wherein R stands for an alkyl group, or a salt thereof is