METHOD OF PREPARING DAUNOMYCINES

METHOD OF PREPARING DAUNOMYCINES

The process for the preparation of daunomycin and of 4'-epi-daunomycin and the corresponding ss anomers comprises reacting daunomycinone with a 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxyhexose which has the L-lyxo or L-arabino configuration in an organic solvent in the pres...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SERDZHIO PENKO,IT, FEDERIKO ARKAMONE,IT, AURELIOMARKO,IT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The process for the preparation of daunomycin and of 4'-epi-daunomycin and the corresponding ss anomers comprises reacting daunomycinone with a 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxyhexose which has the L-lyxo or L-arabino configuration in an organic solvent in the presence of a mercury salt as catalyst and of a hydrogen chloride acceptor and then removing the trifluoroacetyl protective groups in the glycoside compounds which are formed, and separating the alpha and ss anomers. The compounds display excellent biological properties as potent inhibitors of cell mitosis and proliferative activity in cultured cells in vitro.