METHOD OF PREPARING N-CYCLOHEXYL-N-METHYL-N-(2-AMINO-3,5-DIBROMOBENZYL)AMINE

METHOD OF PREPARING N-CYCLOHEXYL-N-METHYL-N-(2-AMINO-3,5-DIBROMOBENZYL)AMINE

For the preparation of N-cyclohexyl-N-methyl-N-(2-amino-3,5-dibromobenzyl)amine, 3-bromo-2-nitrobenzyl bromide is used as a starting substance and is reacted with N-methylcyclohexylamine in the presence of an acid acceptor. The nitro group of the resultant N-cyclohexyl-N-methyl- 2-nitro-3-bromobenzy...

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Bibliographische Detailangaben
Hauptverfasser: PAL VAGO,HU, YANOSH FISHER,HU, YANOSH EGRI,HU, JOZEF RAKOTSI,HU, TAMASH FODOR,HU
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:For the preparation of N-cyclohexyl-N-methyl-N-(2-amino-3,5-dibromobenzyl)amine, 3-bromo-2-nitrobenzyl bromide is used as a starting substance and is reacted with N-methylcyclohexylamine in the presence of an acid acceptor. The nitro group of the resultant N-cyclohexyl-N-methyl- 2-nitro-3-bromobenzylamine is then reduced and the resulting N-cyclohexyl-N-methyl-2-amino-3-bromobenzylamine is brominated. This process enables the preparation of this compound in a simple manner with a yield of more than 80%. The compound has excellent bronchosecretolytic action and can be used in the therapy of chronic, non-specific disorders of the airways.