METHOD OF PREPARING 2-TETRA-HYDROFURFURYL-6,7-BENZOMORPHANES OR SALTS THEREOF

Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R denotes methyl, ethyl or propyl; R denotes hydrogen, methyl or ethyl; R denotes hydrogen or methyl; and R denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by intr...

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Bibliographische Detailangaben
Hauptverfasser:	GERBERT MERTS,DT, KLAUS SHTOKKHAUS,DT, ADOLF LANGBEJN,DT, GERKHARD VALTER,DT
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R denotes methyl, ethyl or propyl; R denotes hydrogen, methyl or ethyl; R denotes hydrogen or methyl; and R denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by introducing the tetrahydrofurfuryl radical into appropriately substituted norbenzomorphans by the methods of N-alkylation. The resulting bases of the formula I can then be converted into their acid addition salts. The compounds of the formula I and their acid addition salts are distinguished by a therapeutically utilisable action on the central nervous system. Particularly to be emphasised is their analgesic action, which frequently exceeds that of morphine, without exhibiting the undesired side effects of morphine, e.g. the addictive action.