METHOD OF PREPARING APYLPYPERAZINE DERIVATIVES OF ADENINE

METHOD OF PREPARING APYLPYPERAZINE DERIVATIVES OF ADENINE

A N6-substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula (I) wherein R1 is hydrogen or a lower alkyl radical, and R2 is a lower alkyl radical, a lower alkyl radical substituted by at least one of phenyl and hydroxyl, a lower alkenyl radical, a cycloalkyl radical or an aryl radical,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VERNER VINTER,DT, ANDRONIKI RESH,DT, MAKS TIL,DT, VOLFGANG SHAUMANN,DT, VALTER-GUNAR FRIBE,DT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A N6-substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula (I) wherein R1 is hydrogen or a lower alkyl radical, and R2 is a lower alkyl radical, a lower alkyl radical substituted by at least one of phenyl and hydroxyl, a lower alkenyl radical, a cycloalkyl radical or an aryl radical, or R1 and R2 together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine or morpholine ring, and R3 is hydrogen, halogen, a lower alkyl radical or a lower alkoxy radical, OR A SALT THEREOF WITH A PHARMACOLOGICALLY COMPATIBLE ACID, WHICH COMPOUNDS ARE CHARACTERIZED BY MARKED ANTI-EDEMATOUS ACTIVITY AS WELL AS BY ACTIVITY IN REDUCING CAPILLARY PERMEABILITY.