(1,2,5-TRIMETHYLPIPERIDYL-4)-DIPHENYLACETATE HYDROCHLORIDE OR CITRATE SHOWING LOCAL ANESTHETIC AND ANTIARRHYTHMIC ACTION

FIELD: organic chemistry. SUBSTANCE: product: (1,2,5-trimethylpiperidyl-4)-diphenylacetate hydrochloride or citrate of the general formulawhere Z - HCL or. Ia: empirical formula is CHNOCl,, yield is 68%, m. p. is 185-187 C; Ib: empirical formula is CHNO, yield is 59%, m. p. is 92-94 C. Reagent 1: (1...

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Hauptverfasser:	Demina L.M, Gerchikov L.N, Prostakov N.S, Borisova T.N, Varlamov A.V, Krapivko A.P
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: organic chemistry. SUBSTANCE: product: (1,2,5-trimethylpiperidyl-4)-diphenylacetate hydrochloride or citrate of the general formulawhere Z - HCL or. Ia: empirical formula is CHNOCl,, yield is 68%, m. p. is 185-187 C; Ib: empirical formula is CHNO, yield is 59%, m. p. is 92-94 C. Reagent 1: (1,2,5-trimethylpiperidyl-4)-diphenylacetate. Reagent 2: hydrogen chloride or citric acid. Reaction conditions: in medium of organic solvent (dioxane or ether). EFFECT: improved method of synthesis. 1 tbl Использование: в качестве веществ, обладающих местноанестезирующим и антиаритмическим действием. Сущность изобретения: продукт - гидрохлорид или цитрат (1,2,5-триметилпиперидил-4)дифенилацетата общей формулыIa БФ CHNOCl, выход 68%, т.пл. 185 - 187C; Iб БФ CHNO, выход 59%, т. пл. 92 - 94C. Реагент 1:(1,2,5-триметилпиперидил-4)-дифенилацетат. Реагент 2: хлористый водород или лимонная кислота. Условия реакции: в среде органического растворителя, такого как диоксан или эфир. 1 табл.