8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2, 4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING

8-AMINO-3-(2-MORPHOLINOETHYLTHIO)-1,2, 4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE PROTECTING LIVER AGAINST CARBON TETRACHLORIDE INTOXICATION AND PROCESS ACCELERATING AFTER PHYSICAL LOADING

FIELD: organic chemistry. SUBSTANCE: product: 8-amino-3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indole of the formula. Empirical formula is CHNS, yield is 73%, m. p. is 165 C. Reagent 1: 3-thiosemicarbazone-5-aminoisatin. Reagent 2: sodium hydroxide solution. Reagent 3: 2-morpholinoethyl-brom...

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Hauptverfasser: Tomchin A.B, Okovityj S.V, Spivakova R.P, Smirnov A.V, Gajvoronskaja V.V
Format: Patent
Sprache:eng ; rus
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: organic chemistry. SUBSTANCE: product: 8-amino-3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b]-indole of the formula. Empirical formula is CHNS, yield is 73%, m. p. is 165 C. Reagent 1: 3-thiosemicarbazone-5-aminoisatin. Reagent 2: sodium hydroxide solution. Reagent 3: 2-morpholinoethyl-bromide hydrobromide. Reagent 4: concentrated HCl. EFFECT: increased yield of product. 2 tbl Сущность изобретения: продукт гидрохлорид 8-амино-3-(2-морфолиноэтилтио)-1,2,4-триазино[5,6-b]индола формулыБФ: CHNS*HCl, выход: 73%, т.пл. 165C. Реагент 1:3-тиосемикарбазон 5-аминоизатина. Реагент 2: раствор едкого натра. Реагент 3: гидробромид 2-морфолиноэтилбромид. Реагент 4: конц. HCl. 2 табл.