METHOD OF SYNTHESIS OF FLUOROALKYL-CONTAINING β-HYDROXYKETONES

METHOD OF SYNTHESIS OF FLUOROALKYL-CONTAINING β-HYDROXYKETONES

FIELD: organic chemistry. SUBSTANCE: product: compound of the formula RCH(OH)CH-C(= O)Ph where R(CF),CF., H(CF),CF., yield is 65-67%. Reagent 1: polyfluorocarboxylic acid ester. Reagent 2: acetophenone. Reaction conditions: lithium hydride, sodium tetrahydroaluminate at molar ratio ester : hydride :...

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Bibliographische Detailangaben
Hauptverfasser: Filjakova V.I, Pashkevich K.I, Ratner V.G, Khomutov O.G
Format: Patent
Sprache:eng ; rus
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:FIELD: organic chemistry. SUBSTANCE: product: compound of the formula RCH(OH)CH-C(= O)Ph where R(CF),CF., H(CF),CF., yield is 65-67%. Reagent 1: polyfluorocarboxylic acid ester. Reagent 2: acetophenone. Reaction conditions: lithium hydride, sodium tetrahydroaluminate at molar ratio ester : hydride : sodium tetrahydroaluminate = 1:(2-3):(0.4-0.5). EFFECT: improved method of synthesis. 1 tbl Сущность изобретения: продукт формулы RCH(OH)CHC(=O)Ph, где R- СF, CF. Н(СF), СF, выход 65-67%. Реагент 1: сложный эфир полифторкарбоновой кислоты. Реагент 2: ацетофенон. Условия реакции: гидрид лития, тетрагидридоалюминат натрия, молярное соотношение эфир: гидрид: тетрагидридоалюминат натрия -1:(2-3)(0,4-0,5). 1 табл.