METHOD OF SYNTHESIS OF BETA-LACTAM DERIVATIVES

METHOD OF SYNTHESIS OF BETA-LACTAM DERIVATIVES

There are provided compounds of the formula Ia and Ib wherein A is hydrogen atom or an organic residue, R is halogen atom, or an organic group, R is hydrogen or halogen atom, C1-C4 alkyl or alkoxy group R is hydrogen atom, C1-C4 alkyl or alkoxy group, benzyl or a methylene group and R4 is an organic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PERDZHUZEPPE ORETSTSI,IT, MARKO ALPEDZHANI,IT, DZHOVANNI FRANCHESKI,IT, ETTORE PERRONE,IT, PERLUIDZHI BISSOLINO,IT
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:There are provided compounds of the formula Ia and Ib wherein A is hydrogen atom or an organic residue, R is halogen atom, or an organic group, R is hydrogen or halogen atom, C1-C4 alkyl or alkoxy group R is hydrogen atom, C1-C4 alkyl or alkoxy group, benzyl or a methylene group and R4 is an organic residue. Said derivatives (Ia) and (Ib) are endowed with elastase inhibitory activity. A two-step process for their preparation starting from the corresponding 4-carboxy cephem or 3-carboxy penam is also provided.