METHOD OF PREPARATION OF 2-GUANIDINO-4-AMIDINOTHIOMETHYLTHIAZOL

METHOD OF PREPARATION OF 2-GUANIDINO-4-AMIDINOTHIOMETHYLTHIAZOL

A method for preparing 2-guanidinothiazole derivs. of formula (I) comprises (A) reacting amidinothiourea of formua (II) with 1,3dihaloacetone to produce a cpd. of formula (III) (B) and then reacting (III) with thiourea in the pressence of water. In the formulas, Y is -C(NH2)NH; X is halogen. (I) act...

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Bibliographische Detailangaben
Hauptverfasser: ERIK BOGSH,HU, PETER BOD,HU, FERENTS TRISHLER,HU, EVA AGAJNE CHONGOR,HU, KALMAN KHARSHANI,HU
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A method for preparing 2-guanidinothiazole derivs. of formula (I) comprises (A) reacting amidinothiourea of formua (II) with 1,3dihaloacetone to produce a cpd. of formula (III) (B) and then reacting (III) with thiourea in the pressence of water. In the formulas, Y is -C(NH2)NH; X is halogen. (I) active against gastric acid secretion.