METHOD OF PRODUCING (-)-3S,16R,14R-14,15-DIHYDRO-14-HYDROXYMETHYL-EBURINEAMENINE

The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) (Ia) or (Ib), (Ib) wherein R1 stands for a C1-4 alkyl group; and R stands for hydrogen, a C1-6 alkyl group, a C2-6 alkenyl group, an acyl or su...

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Hauptverfasser: EGON KARPATI,HU, LASLO SPORNI,HU, LASLO TSIBULA,HU, BELA SHTEFKO,HU, BELA KISHSH,HU, ANIKO GERE,HU, YANOSH KRAJDL,HU, CHABA KUTI,HU, MARIYA FARKASH,HU, LILLA FORGACH,HU, KATALIN CHOMOR,HU, ZHOLT SOMBATELI,HU, DERD VISHKI,HU
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:The invention relates to the preparation of cis and trans stereoisomers of racemic and optically active eburnamenine derivatives of the general formula (Ia) (Ia) or (Ib), (Ib) wherein R1 stands for a C1-4 alkyl group; and R stands for hydrogen, a C1-6 alkyl group, a C2-6 alkenyl group, an acyl or substituted acyl group, as well as their acid addition salts, of which the trans compounds are novel. The invention also relates to the compounds of the general formula (IIIa) (IIIa) and (IIIb), (IIIb) wherein R1 and R' represent a C1-4 alkyl group. The compounds of the general formulae (Ia) and (Ib) possess a vasodilatory effect which is substantially higher than that of pentoxifyllin, a known peripheral vasodilator.