METHOD OF OBTAINING DERIVATIVES OF 1,4 DIHYDROPYRIDINE OR THEIR HYDROCHLORIDES

1,4-Dihydropyridine derivatives of the formula:-and their pharmaceutically acceptable acid addition salts; whereR is aryl or heteroaryl;R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl;Y is -(CH2)2-, -(CH2)3-, -CH2CH(CH3)- or -CH2C(CH3)2-;R3 is hydrogen or a group selected from:-where R4 is H, C1-C4 alkyl, C3-C6 cycloalkyl, -COO(C1-C4 alkyl), -CH2COO(C1-C4 alkyl), aryl, -S02.aryl, or heteroaryl, and X is 0 or S;where R5 is 1-pyrrolidinyl, -NH2, -NH(C1-C4 alkyl), -N/C1-C4 alkyl)2, or -NH(CH2)2N(C1-C4 alkyl)2;where R6 is C1-C4 alkyl or aryl;where R7 is -CONH(C1-C4 alkyl) or -COO(C1-C4 alkyl);where R8 is -CN, -SO2(C1-C4 alkyl) or -SO2 aryl;(h) -CH2CO.R9 where R9 is -NH2, -NH(C1-C4 alkyl), -NH.aryl or C1-C4 alkoxy;(i) -SO2.R10 where R10 is -NH2, -N(C1-C4 alkyl)2 or C1-C4 alkyl; and(j) -CO.R" where R" is H, halomethyl, -COO(C1-C4 alkyl), -CH2O(C1-C4 alkyl), -CH2CO(C1-C4 alkyl), C1-C4 alkyl, C1-C4 alkoxy, aryl, heteroaryl, morpholino or 5-oxo-pyrrolidin-2-yl.The compounds have utility as anti-ischaemic and antihypertensive agents.