METHOD OF SYNTHESIS OF 2-(2,2,5,5-TETRAMETHYL-3-CYANOMETHYLID- -ENE-6-CYANOMETHYLENE-1,4-DIOXANYL-2)-THIOPYRIMIDINE
FIELD: organic chemistry and technology, heterocyclic compounds. SUBSTANCE: product: 2-(2,2,5,5-tetramethyl-3-cyanomethylidene- -1,4-dioxanyl-2)-thiopyrimidine. Method involves interaction of pyrimidine-2-thione with tertiary cyanomethylene alcohol of the formula (CH)C(OH) ≡ CCN in dioxane medium in...
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| creator | Abramova N.D Andrijankova L.V Mal'kina A.G Skvortsov Ju.M Domnina E.S |
| description | FIELD: organic chemistry and technology, heterocyclic compounds. SUBSTANCE: product: 2-(2,2,5,5-tetramethyl-3-cyanomethylidene- -1,4-dioxanyl-2)-thiopyrimidine. Method involves interaction of pyrimidine-2-thione with tertiary cyanomethylene alcohol of the formula (CH)C(OH) ≡ CCN in dioxane medium in the presence of lithium hydroxide at amount 10% of the parent thione mass. Reaction is carried out at two-fold alcohol excess, at room temperature for 10-12 h. M.p. is 195-197 C, yield is 70%. Synthesized compound is used for synthesis of bioactive substances. EFFECT: improved method of synthesis, increased yield.
Изобретение относится к химии гетероциклических соединений, в частности к 2-(2,2,5,5-тетраметил-3-цианометилиден-6- цианометилен-1,4-диоксанил-2-)тиопиримидину для синтеза биологически активных веществ. Новый способ получения новых производных гетерилпиримидинов по более простой схеме осуществляют путем взаимодействия пиримидин-2-тиона с третичным цианометиленовым спиртом (CH)C(OH)C= CCN в среде диоксана в присутствии гидроокиси лития в количестве 10% от массы исходного тиона. Реакцию проводят с двухкратным избытком спирта при комнатной температуре в течение 10-12 ч, т.пл. 195-197C, выход 70%. |
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Изобретение относится к химии гетероциклических соединений, в частности к 2-(2,2,5,5-тетраметил-3-цианометилиден-6- цианометилен-1,4-диоксанил-2-)тиопиримидину для синтеза биологически активных веществ. Новый способ получения новых производных гетерилпиримидинов по более простой схеме осуществляют путем взаимодействия пиримидин-2-тиона с третичным цианометиленовым спиртом (CH)C(OH)C= CCN в среде диоксана в присутствии гидроокиси лития в количестве 10% от массы исходного тиона. Реакцию проводят с двухкратным избытком спирта при комнатной температуре в течение 10-12 ч, т.пл. 195-197C, выход 70%.</description><language>eng ; rus</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970520&DB=EPODOC&CC=SU&NR=1304356A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970520&DB=EPODOC&CC=SU&NR=1304356A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Abramova N.D</creatorcontrib><creatorcontrib>Andrijankova L.V</creatorcontrib><creatorcontrib>Mal'kina A.G</creatorcontrib><creatorcontrib>Skvortsov Ju.M</creatorcontrib><creatorcontrib>Domnina E.S</creatorcontrib><title>METHOD OF SYNTHESIS OF 2-(2,2,5,5-TETRAMETHYL-3-CYANOMETHYLID- -ENE-6-CYANOMETHYLENE-1,4-DIOXANYL-2)-THIOPYRIMIDINE</title><description>FIELD: organic chemistry and technology, heterocyclic compounds. SUBSTANCE: product: 2-(2,2,5,5-tetramethyl-3-cyanomethylidene- -1,4-dioxanyl-2)-thiopyrimidine. Method involves interaction of pyrimidine-2-thione with tertiary cyanomethylene alcohol of the formula (CH)C(OH) ≡ CCN in dioxane medium in the presence of lithium hydroxide at amount 10% of the parent thione mass. Reaction is carried out at two-fold alcohol excess, at room temperature for 10-12 h. M.p. is 195-197 C, yield is 70%. Synthesized compound is used for synthesis of bioactive substances. EFFECT: improved method of synthesis, increased yield.
Изобретение относится к химии гетероциклических соединений, в частности к 2-(2,2,5,5-тетраметил-3-цианометилиден-6- цианометилен-1,4-диоксанил-2-)тиопиримидину для синтеза биологически активных веществ. Новый способ получения новых производных гетерилпиримидинов по более простой схеме осуществляют путем взаимодействия пиримидин-2-тиона с третичным цианометиленовым спиртом (CH)C(OH)C= CCN в среде диоксана в присутствии гидроокиси лития в количестве 10% от массы исходного тиона. Реакцию проводят с двухкратным избытком спирта при комнатной температуре в течение 10-12 ч, т.пл. 195-197C, выход 70%.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1997</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7EKwjAURbs4iPoPGRXywCZt99C8kgc2kSaCmUqROIkW6v-jRQdHp8s5nLvMphaDcZq5hvlog0FPfgYBW8EFL3kJAUOn5iweQEIdlXUfIg0M0CJUv3YWOS9Akzsr-_6IHQRD7hg7akmTxXW2uA63KW2-u8pYg6E2kMZHn6ZxuKR7evb-lMt9IctK5fKP5AVfrjdG</recordid><startdate>19970520</startdate><enddate>19970520</enddate><creator>Abramova N.D</creator><creator>Andrijankova L.V</creator><creator>Mal'kina A.G</creator><creator>Skvortsov Ju.M</creator><creator>Domnina E.S</creator><scope>EVB</scope></search><sort><creationdate>19970520</creationdate><title>METHOD OF SYNTHESIS OF 2-(2,2,5,5-TETRAMETHYL-3-CYANOMETHYLID- -ENE-6-CYANOMETHYLENE-1,4-DIOXANYL-2)-THIOPYRIMIDINE</title><author>Abramova N.D ; Andrijankova L.V ; Mal'kina A.G ; Skvortsov Ju.M ; Domnina E.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_SU1304356A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; rus</language><creationdate>1997</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>Abramova N.D</creatorcontrib><creatorcontrib>Andrijankova L.V</creatorcontrib><creatorcontrib>Mal'kina A.G</creatorcontrib><creatorcontrib>Skvortsov Ju.M</creatorcontrib><creatorcontrib>Domnina E.S</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Abramova N.D</au><au>Andrijankova L.V</au><au>Mal'kina A.G</au><au>Skvortsov Ju.M</au><au>Domnina E.S</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHOD OF SYNTHESIS OF 2-(2,2,5,5-TETRAMETHYL-3-CYANOMETHYLID- -ENE-6-CYANOMETHYLENE-1,4-DIOXANYL-2)-THIOPYRIMIDINE</title><date>1997-05-20</date><risdate>1997</risdate><abstract>FIELD: organic chemistry and technology, heterocyclic compounds. SUBSTANCE: product: 2-(2,2,5,5-tetramethyl-3-cyanomethylidene- -1,4-dioxanyl-2)-thiopyrimidine. Method involves interaction of pyrimidine-2-thione with tertiary cyanomethylene alcohol of the formula (CH)C(OH) ≡ CCN in dioxane medium in the presence of lithium hydroxide at amount 10% of the parent thione mass. Reaction is carried out at two-fold alcohol excess, at room temperature for 10-12 h. M.p. is 195-197 C, yield is 70%. Synthesized compound is used for synthesis of bioactive substances. EFFECT: improved method of synthesis, increased yield.
Изобретение относится к химии гетероциклических соединений, в частности к 2-(2,2,5,5-тетраметил-3-цианометилиден-6- цианометилен-1,4-диоксанил-2-)тиопиримидину для синтеза биологически активных веществ. Новый способ получения новых производных гетерилпиримидинов по более простой схеме осуществляют путем взаимодействия пиримидин-2-тиона с третичным цианометиленовым спиртом (CH)C(OH)C= CCN в среде диоксана в присутствии гидроокиси лития в количестве 10% от массы исходного тиона. Реакцию проводят с двухкратным избытком спирта при комнатной температуре в течение 10-12 ч, т.пл. 195-197C, выход 70%.</abstract><oa>free_for_read</oa></addata></record> |
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| title | METHOD OF SYNTHESIS OF 2-(2,2,5,5-TETRAMETHYL-3-CYANOMETHYLID- -ENE-6-CYANOMETHYLENE-1,4-DIOXANYL-2)-THIOPYRIMIDINE |
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