METHOD OF PRODUCING DERIVATIVES OF 2,4-DIAMINO-5-BENZYLPYRIMIDINE

2,4-Diamino-5-benzyl-pyrimidine derivatives (antibacterials) of the formula (R1 and R3 represent hydrogen, a methyl group or a methoxy group; R2 is a halogen, a C1-4 alkoxy group substituted with a halogen, a C2-4 alkenyloxy group or an R4O(R5O)n group; R4 is a C1-4 alkyl group; R5 a C1-4 alkylene g...

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Bibliographische Detailangaben
Hauptverfasser:	EVA FURDIGA,HU, ISHTVAN SHIMONI,HU, IVAN BEK,HU, YANOSH EGRI,HU, DERDI KOVANI,HU, ELEMER YAKFALVI,HU
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	2,4-Diamino-5-benzyl-pyrimidine derivatives (antibacterials) of the formula (R1 and R3 represent hydrogen, a methyl group or a methoxy group; R2 is a halogen, a C1-4 alkoxy group substituted with a halogen, a C2-4 alkenyloxy group or an R4O(R5O)n group; R4 is a C1-4 alkyl group; R5 a C1-4 alkylene group; n is 1 or 2), and their acid addition salts are prepared by reacting an alpha - benzal- beta -methoxypropionitrile of the formula with a diethylene glycol monoalkyl ether in the presence of a base, cyclising the thus-obtained benzyl isomer of the formula (preferably without separation) with quanidine and, if desired, converting the product to a salt.